Egg Shell Membrane in US 2025 | Statistics & Facts

Egg Shell Membrane in US 2025

The egg shell membrane market in the US 2025 represents a rapidly expanding segment of the natural health and wellness industry, driven by increasing consumer demand for sustainable, bioactive ingredients that support joint health, skin vitality, and overall well-being. Egg shell membrane is the thin, translucent layer located between the hard eggshell and the egg white, composed of naturally occurring proteins, glycosaminoglycans, and collagen that provide structural support and nutritional benefits. This natural biomaterial, once considered a waste product of the egg-breaking industry, has emerged as a valuable ingredient in nutraceutical supplements, cosmetic formulations, and functional foods, transforming how manufacturers approach joint care and anti-aging solutions.

The United States stands as a dominant force in the global egg shell membrane industry, with North American markets accounting for over 49.33 million USD in revenue during 2022 and projected to reach 612.4 million USD by the forecast period. American companies including Biova LLC, ESM Technologies, and Certified Nutraceuticals Inc. lead innovation in extraction technologies, clinical research, and commercialization of branded ingredients that set industry standards for purity, bioavailability, and efficacy. The U.S. market benefits from abundant raw material supply, with the country producing millions of tons of eggs annually and generating substantial eggshell waste that can be upcycled into high-value membrane ingredients. As consumers increasingly seek clean-label, traceable ingredients backed by scientific evidence, egg shell membrane products have gained traction across dietary supplement retailers, e-commerce platforms, and professional healthcare channels, positioning the U.S. as both a manufacturing hub and a primary consumer market for these innovative natural ingredients in 2025.

Interesting Facts About Egg Shell Membrane in the US in 2025

Data Source: Fortune Business Insights, GM Insights, Biova LLC, ESM Technologies, Market Research Future, Straits Research

The egg shell membrane statistics presented above demonstrate the remarkable growth trajectory and therapeutic potential of this natural ingredient in the United States in 2025. The US market valuation growing from 49.33 million USD in 2022 to a projected 612.4 million USD represents a dramatic expansion fueled by clinical validation, consumer awareness, and innovative product formulations. The proven 500 mg daily dosage has become the industry standard following multiple randomized controlled trials demonstrating efficacy, making product development straightforward for supplement manufacturers seeking evidence-based ingredient solutions.

Particularly compelling is the rapid onset of therapeutic benefits, with clinical studies consistently showing pain relief within 7-10 days of supplementation initiation. This quick response time significantly outperforms traditional joint health ingredients like glucosamine and chondroitin sulfate, which typically require weeks or months to demonstrate measurable effects. The 50% pain reduction achieved in most study participants represents clinically meaningful improvement that translates to enhanced quality of life for individuals suffering from osteoarthritis and joint discomfort. Additionally, the sustainability profile adds consumer appeal, with leading U.S. companies like Biova diverting over 2 billion eggshells annually from landfills, transforming food industry waste into premium health ingredients. The >85% protein concentration achieved through advanced extraction technologies ensures that products deliver concentrated bioactive compounds including collagen, elastin, glycosaminoglycans, and amino acids in their naturally occurring ratios.

Egg Shell Membrane Market Size and Growth in the US 2025

Data Source: Straits Research, Data Bridge Market Research, GM Insights, Research and Markets, Fortune Business Insights

The egg shell membrane market size in the US 2025 reflects extraordinary expansion across multiple valuation models, with the global market growing from 173.78 million USD in 2024 to a projected 396.55 million USD by 2033, representing a compound annual growth rate of 9.6%. The United States maintains its position as the largest regional market, with North American revenues of 49.33 million USD in 2022 and projections reaching 612.4 million USD during the forecast period. This growth trajectory reflects multiple converging factors: aging demographics driving demand for joint health solutions, increasing consumer preference for natural ingredients over synthetic alternatives, expanded distribution through e-commerce channels, and mounting clinical evidence supporting efficacy claims.

The eggshell membrane powder market presents even more dramatic growth figures, valued at 1.44 billion USD in 2024 and expected to reach 2.80 billion USD by 2032 at a CAGR of 8.7%. This larger market valuation reflects broader product applications beyond traditional supplements, including functional foods, cosmetic formulations, and pharmaceutical applications. The dietary supplements segment alone accounted for 40.12 million USD in 2022, with the powder form dominating at 72.71% market share due to versatility in product formulations. Regional growth patterns show the Asia Pacific region emerging as the fastest-growing market with a projected 12% CAGR, driven by rising disposable incomes, increasing health consciousness, and growing awareness of natural joint health solutions, though the United States retains market leadership in both consumption and innovation. The nutraceutical and pharmaceutical industries drive much of this expansion, as manufacturers reformulate existing products and launch new offerings incorporating eggshell membrane ingredients to meet consumer demand for evidence-based, natural health solutions.

Key Egg Shell Membrane Companies and Manufacturers in the US 2025

Data Source: Company websites, Market research reports, Industry publications, Biova LLC, ESM Technologies

Leading egg shell membrane companies in the US 2025 have established themselves as innovation drivers through proprietary extraction technologies, clinical research investments, and strategic partnerships with egg-breaking facilities. Biova LLC, headquartered in Johnston, Iowa, stands out as a market leader with its patented water-soluble egg membrane technology that enables product incorporation into beverages, gummies, and functional foods beyond traditional capsules and tablets. The company’s branded ingredients—BiovaFlex® for joint health, BiovaDerm® for topical skin applications, BiovaBIO® for beauty-from-within supplements, and BiovaPlex® for pet health—demonstrate comprehensive market coverage. Biova works with the largest egg production facilities in the United States, diverting over 2 billion eggshells from landfills annually while maintaining >85% protein content through gentle hydrolysis processes.

ESM Technologies LLC in Carthage, Missouri pioneered the commercialization of eggshell membrane with its NEM® (Natural Eggshell Membrane) ingredient, which received the 2011 North American Dietary Supplements for Joint Health New Product Innovation Award. The company operates an NSF GMP certified facility and uses chemical-free, patented processes to produce shell-free eggshell membrane that maintains naturally occurring ratios of collagen, glycosaminoglycans, and proteins. ESM Technologies sources from USDA-inspected egg-breaking facilities, ensuring traceability and food safety compliance. Following resolution of patent litigation in 2012, both Biova and ESM Technologies agreed to coexist in the marketplace, allowing each company to continue marketing their respective products and driving innovation through competitive differentiation. Certified Nutraceuticals Inc. partners with these manufacturers to supply NEM® ingredients to the broader dietary supplement industry, while Stratum Nutrition provides additional distribution channels to functional food and supplement makers. The presence of these established U.S. companies, combined with international players like Kewpie Corporation operating in American markets, creates a robust competitive landscape that drives quality improvements, price optimization, and continued research investments.

Joint Health Benefits of Egg Shell Membrane in the US 2025

Data Source: Clinical Interventions in Aging, Clinical Rheumatology, Journal of Functional Foods, PubMed Central, National Library of Medicine

Joint health benefits represent the primary clinical application of egg shell membrane in the US 2025, with robust evidence from multiple randomized, double-blind, placebo-controlled trials demonstrating significant improvements in pain, stiffness, and functional mobility for individuals suffering from osteoarthritis. The landmark OPTION trial (Osteoarthritis Pain Treatment IncorpOrating NEM®) evaluated 500 mg daily supplementation and found statistically significant pain reduction beginning at 10 days, with approximately 15% mean response rates for WOMAC pain and stiffness subscores. By 60 days, stiffness improvements reached 26.6%—a clinically meaningful improvement that translates to enhanced quality of life for arthritis sufferers.

The mechanism of action involves multiple pathways: eggshell membrane naturally contains collagen type I, glycosaminoglycans including glucosamine and chondroitin sulfate, hyaluronic acid, and structural proteins that provide the building blocks for cartilage repair and synovial fluid production. Clinical studies demonstrate that supplementation reduces pro-inflammatory cytokines—biochemical signals that trigger joint pain and cartilage destruction—while simultaneously supporting tissue regeneration. A study of 60 healthy postmenopausal women showed significant reduction in cartilage turnover biomarkers after just one week of supplementation, with continued protection against exercise-induced joint damage. The rapid onset of benefits (7-10 days) significantly outperforms traditional joint supplements like glucosamine and chondroitin, which typically require 6-8 weeks or longer to demonstrate measurable effects. The 50% pain reduction achieved in most study participants represents clinically meaningful improvement, and the excellent safety profile with no serious adverse events reported makes eggshell membrane an attractive alternative to NSAIDs, which carry risks of gastrointestinal complications, cardiovascular events, and kidney damage with long-term use.

Skin Health and Cosmetic Applications of Egg Shell Membrane in the US 2025

Data Source: Clinical, Cosmetic and Investigational Dermatology, Journal of Cosmetic Dermatology, Biova LLC research, Market Research Future

Skin health applications of egg shell membrane have gained substantial traction in the US cosmetics and personal care market in 2025, driven by consumer demand for natural anti-aging ingredients backed by clinical evidence. A 2020 study published in Clinical, Cosmetic and Investigational Dermatology demonstrated that 12 weeks of oral eggshell membrane supplementation produced visible wrinkle reduction, improved skin elasticity, and enhanced hydration in study participants. These benefits stem from the ingredient’s rich composition of collagen, elastin, hyaluronic acid, and glycosaminoglycans—the fundamental building blocks that maintain skin structure, moisture retention, and youthful appearance.

Biova LLC pioneered the beauty-from-within category with BiovaBIO®, a water-soluble eggshell membrane ingredient specifically formulated for oral beauty supplements. Published research in the Journal of Cosmetic Dermatology confirmed that 450 mg daily supplementation with BiovaBIO® produced measurable skin tone improvements after 8 weeks, validating the nutricosmetic approach to skin health. The ingredient provides amino acids that serve as precursors for collagen synthesis, while desmosine and isodesmosine—unique elastin building blocks—support skin elasticity and resilience. For topical applications, BiovaDerm® offers cosmetic formulators a water-soluble ingredient that can be incorporated into serums, creams, and masks, providing direct delivery of skin-supporting compounds. The cosmetics industry’s adoption of eggshell membrane reflects broader consumer trends favoring clean beauty, sustainable sourcing, and science-backed ingredients over synthetic alternatives. The neutral taste and odor profile of high-quality eggshell membrane ingredients enables seamless integration into beauty beverages, gummies, and confectionery products, expanding delivery options beyond traditional capsules. As the US cosmetics and personal care market continues growing, eggshell membrane ingredients are positioned to capture increasing market share within the anti-aging, skin health, and nutricosmetic segments.

Bioactive Components and Nutritional Profile of Egg Shell Membrane in the US 2025

Data Source: PubMed Central research studies, ESM Technologies, Biova LLC, Scientific literature reviews

The bioactive components of egg shell membrane create a unique nutritional matrix that distinguishes this ingredient from isolated supplements like glucosamine or chondroitin alone. Collagen type I comprises over 80% of the membrane’s protein content, providing the structural framework for cartilage, bones, skin, and connective tissues throughout the body. Unlike synthetic collagen supplements derived from bovine, porcine, or marine sources, eggshell membrane collagen maintains its native triple-helix structure through gentle extraction processes, potentially enhancing bioavailability and biological activity. The presence of collagen types V and X adds additional functionality, with type V supporting tissue repair and type X playing specialized roles in bone formation.

Glycosaminoglycans represent the second major bioactive class, with chondroitin sulfate, dermatan sulfate, and hyaluronic acid naturally occurring in ratios optimized by nature for joint and connective tissue support. Glucosamine—typically sold as a standalone supplement at 1,500 mg daily doses—occurs naturally within the eggshell membrane matrix alongside complementary compounds that may enhance its absorption and utilization. Hyaluronic acid content provides dual benefits: within joints, it maintains synovial fluid viscosity for smooth movement and shock absorption, while systemically it supports skin hydration and plumpness. Elastin and its unique cross-linking amino acids desmosine and isodesmosine provide functionality rarely found in dietary sources, supporting tissue elasticity in skin, blood vessels, and lungs. These compounds also stimulate endogenous collagen synthesis, amplifying benefits beyond direct supplementation. The antimicrobial proteins lysozyme and ovotransferrin add immune-supporting properties, while the complete amino acid profile including essential amino acids provides raw materials for tissue repair and regeneration. This comprehensive nutritional composition explains why clinical studies consistently demonstrate superior efficacy for eggshell membrane compared to isolated joint health ingredients—the synergistic combination of bioactive compounds working together produces effects greater than the sum of individual parts.

Clinical Research and Scientific Evidence for Egg Shell Membrane in the US 2025

Data Source: PubMed Central, National Library of Medicine, Clinical journals, ScienceDirect, MDPI Nutrients

Clinical research supporting egg shell membrane efficacy in the US 2025 encompasses multiple randomized controlled trials, systematic reviews, and mechanistic studies published in peer-reviewed medical journals. The landmark OPTION trial (Osteoarthritis Pain Treatment IncorpOrating NEM®) established the evidence foundation, enrolling patients with moderate knee osteoarthritis in a multicenter, double-blind, placebo-controlled design. Results demonstrated statistically significant improvements in Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index scores for both pain and stiffness, with responses evident as early as 10 days and sustained through 60 days of supplementation. The rapid onset of benefits distinguishes eggshell membrane from slower-acting alternatives like glucosamine and chondroitin, which failed to show significant improvement in the NIH-sponsored GAIT trial involving 1,583 patients.

A 2024 systematic review and meta-analysis published in Nutrients (MDPI) analyzed 7 randomized controlled trials meeting rigorous inclusion criteria, with 5 studies included in the quantitative meta-analysis. Results indicated that eggshell membrane supplementation significantly reduced pain and improved functionality in individuals with knee osteoarthritis, with effect sizes of −0.34 (95% CI: −0.56 to −0.13) for total WOMAC scores. The review evaluated outcomes using standardized assessment tools including WOMAC, Visual Analogue Scale (VAS), and Knee Injury and Osteoarthritis Outcome Score (KOOS), providing comprehensive evidence across multiple pain and function measures. Innovative research from 2024 published in the Journal of Functional Foods demonstrated that freshness of eggshell membrane significantly impacts therapeutic efficacy, with MKARE®—processed from fresh membranes—showing superior anti-inflammatory capacity compared to commercially available products derived from eggshells stored at room temperature for days, resulting in protein degradation and reduced bioactive compound retention.

The bone health applications have also gained scientific support, with a 2024 systematic review in PMC evaluating eggshell membrane as a supplement to prevent bone loss, noting that the similar organic composition of ESM and human bone—both primarily consisting of collagen type I, chondroitin sulfate, dermatan sulfate, hyaluronic acid, and elastin—suggests therapeutic potential for osteoporosis. Clinical studies report that ESM intake reduced pain in patients with joint disorders, reduced inflammatory processes, and improved calcium uptake in human cells, supporting bone health through multiple mechanisms. The skin health evidence base expanded with a 2020 publication in Clinical, Cosmetic and Investigational Dermatology demonstrating that 12 weeks of oral eggshell membrane supplementation produced visible wrinkle reduction, improved skin elasticity, and enhanced hydration. The accumulation of positive clinical evidence across joint health, bone health, and skin health applications has established eggshell membrane as an evidence-based ingredient in the U.S. market, supporting regulatory approvals, health claims, and consumer confidence.

Extraction and Processing Technologies for Egg Shell Membrane in the US 2025

Data Source: Company patents, Journal of Functional Foods, Market Research Reports, Biova LLC, ESM Technologies

Extraction and processing technologies represent critical determinants of egg shell membrane quality in the US 2025, with proprietary methods creating competitive advantages through enhanced purity, bioavailability, and application versatility. Biova LLC’s patented water-soluble extraction process stands as an industry innovation, using gentle hydrolysis techniques that maintain natural nutrient ratios while creating a water-soluble ingredient suitable for beverages, gummies, stick packs, and functional foods—applications impossible with conventional non-water-soluble eggshell membrane powders. The process achieves >85% protein content and removes inorganic eggshell material (calcium carbonate), resulting in a high-purity ingredient with low calcium content and excellent organoleptic properties (neutral taste and odor).

ESM Technologies pioneered the chemical-free separation process for NEM®, using mechanical methods to efficiently separate membrane from eggshells, creating an essentially shell-free product that maintains the native bioactive compound matrix. The company operates NSF GMP certified facilities and sources from USDA-inspected egg-breaking plants, ensuring traceable supply chains and food safety compliance. Their partial hydrolysis process involves proprietary dry blending techniques that produce 100% pure Natural Eggshell Membrane without chemical solvents or harsh treatments that could denature proteins or destroy sensitive bioactive compounds. Research published in the Journal of Functional Foods in 2024 demonstrated that processing freshness significantly impacts therapeutic efficacy: MKARE®, manufactured from eggshells processed immediately after breaking, showed superior anti-inflammatory effects compared to products derived from eggshells stored at room temperature for several days. The study used OPA (o-phthaldialdehyde) testing to quantify protein degradation, finding that room-temperature storage promoted microbial growth and protein breakdown, reducing free amino group content and changing membrane appearance from white-pink to brown.

The industry offers both unhydrolyzed and hydrolyzed eggshell membrane products, with unhydrolyzed versions maintaining complete native protein structures potentially offering superior biological activity, while hydrolyzed versions may provide enhanced digestibility and bioavailability through partial protein breakdown. The powder form dominates commercial production, capturing 72.71% market share due to versatility in formulation—powders can be encapsulated, tableted, mixed into beverages, or incorporated into food matrices. Advanced processing ensures low microbial counts, controlled particle size distribution, and consistent batch-to-batch quality, meeting stringent specifications required by pharmaceutical, nutraceutical, and cosmetic manufacturers. The sustainability profile of U.S. extraction technologies adds value, with major producers partnering with large egg-breaking facilities to recover membranes that would otherwise be discarded, transforming food industry waste into premium ingredients while minimizing water and energy usage through efficient processing systems.

Applications and Product Formats of Egg Shell Membrane in the US 2025

Data Source: GM Insights, Market Research Future, Biova LLC, Fortune Business Insights, UnivDatos Market Insights

Applications of egg shell membrane in the US 2025 span multiple industries, with the dietary supplements segment maintaining dominance at 40.12 million USD revenue in 2022, driven by aging demographics and increasing prevalence of osteoarthritis. The standard 500 mg capsule format enables once-daily dosing based on clinical trial protocols, simplifying consumer compliance and product marketing. Traditional capsules and tablets serve as primary delivery vehicles, though innovation in powder formats has captured 72.71% market share due to versatility—powders can be incorporated into protein shakes, smoothies, and custom supplement regimens, appealing to consumers seeking flexible dosing options.

The food and beverage sector represents the fastest-growing application area, particularly enabled by water-soluble eggshell membrane technologies from companies like Biova. Functional beverages incorporating joint health ingredients appeal to active adults seeking convenient nutrition, while protein bars, fortified cereals, and nutritional shakes provide additional delivery platforms. The cosmetics and personal care industry has embraced eggshell membrane for both oral beauty supplements and topical applications, with anti-aging serums, moisturizing creams, and facial masks leveraging the ingredient’s collagen, elastin, and hyaluronic acid content. The nutricosmetic category—beauty-from-within supplements—has gained particular traction, with clinical evidence supporting oral supplementation for skin health outcomes.

Disclaimer: This research report is compiled from publicly available sources. While reasonable efforts have been made to ensure accuracy, no representation or warranty, express or implied, is given as to the completeness or reliability of the information. We accept no liability for any errors, omissions, losses, or damages of any kind arising from the use of this report.

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